Matched pair analyse medizin

Über 80% neue Produkte zum Festpreis; Das ist das neue eBay. Finde ‪Medizinisches‬! Riesenauswahl an Markenqualität. Folge Deiner Leidenschaft bei eBay Bei uns finden Sie passende Fernkurse für die Weiterbildung von zu Hause Matched Pair-Analyse zwischen Aus der Klinik für Orthopädie und Rheumatologie des Fachbereiches Medizin der Philipps-Universität Marburg in Zusammenarbeit mit dem Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg Direktorin: Frau Univ.-Prof. Dr. med. Susanne Fuchs-Winkelman

Beurteilung, Auswertung und Publikation von prospektiven Matched-Pairs-Studien Eine bewährte Methode zur Erreichung der Vergleichbarkeit zweier Gruppen in prospektiven Beobachtungsstudien ist die Matched-Pair-Bildung, wie sie in den epidemiologischen Studien von Grossarth-Maticek angewandt wurde Matched-Pair-Analyse: Intensitätsmodulierte Radiotherapie (IMRT) versus 3D- konformale Radiotherapie. Akut- und Spättoxizität der Bestrahlung von Patienten mit Prostatakarzinom Darüber hinaus führen wir, als wissenschaftliche Mitarbeiter und Mediziner der DKMS, eigene Studien im Bereich Stammzellspende und -transplantation durch, um die Sicherheit und Erfolgschancen von Stammzellenspenden noch weiter zu verbessern. Eine solche Studie ist auch das so genannte Matched Pair-Spendernachbeobachtungsprogramm Hierzu wurden die NCB-Platte (polyaxial), sowie die PHILOS-Platte (monoaxial) ausgewählt. Als Design für diese Studie wurde eine Matched Pair-Analyse gewählt in die insgesamt 76 Patienten (=38 Paare) eingeschlossen werden konnten. Matching-Kriterien waren das Alter und Geschlecht der Patienten, sowie der Frakturtyp nach AO-Klassifikation (Weitergeleitet von Matched Pairs) Ein Paarvergleich ist eine Vergleichsmethode, bei der einzelne Objekte paarweise verglichen werden. Im Gegensatz dazu wird bei der Skalierung bzw. Ranking jedes Objekt einzeln betrachtet und auf einer Skala einsortiert

Aufgabe 10: Fall-Kontroll-Studien − Matched-Pairs-Technik Warum wird bei einigen Fall-Kontroll-Studien die Matched-Pairs-Technik angewandt?. Um gleich große Gruppen zu erhalten. Um Strukturgleichheit zu erreichen. Um Beobachtungsgleichheit zu erreichen Typisches Beispiel für Paare sind Untersuchungen, die jeweils an einem Auge oder einem Arm derselben Person durchgeführt werden. Typisch für verbundene Designs sind auch Vergleich vor und nach.. Matching bzw. deutsch paarweise Zuordnung bezeichnet in der Statistik Methoden, mit denen ähnliche Beobachtungen in zwei oder mehr Datensätzen verbunden werden. Mit Matching-Methoden wird anhand gemeinsamer Merkmale den Beobachtungen aus einem Datensatz eine oder mehrere ähnliche Beobachtungen aus den anderen Datensätzen zugeordnet MEDIZIN: Übersichtsarbeit Propensity Score - eine alternative Methode zur Analyse von Therapieeffekten Teil 23 der Serie zur Bewertung wissenschaftlicher Publikatione

Matched Square Pairs, an extension of MMP analysis, can allow a judgement of the quality of generalized relationships. By looking at squares (pairs of matched-pairs) it is possible to check for non-additivity and for outliers. The matched square shows four transforms, which could involve a change of the core and two R-groups or one core and three R-groups as shown i Matched molecular pair analysis (MMPA) is a method in cheminformatics that compares the properties of two molecules that differ only by a single chemical transformation, such as the substitution of a hydrogen atom by a chlorine one. Such pairs of compounds are known as matched molecular pairs (MMP). Because the structural difference between the two molecules is small, any experimentally. Pairwise comparison generally is any process of comparing entities in pairs to judge which of each entity is preferred, or has a greater amount of some quantitative property, or whether or not the two entities are identical.The method of pairwise comparison is used in the scientific study of preferences, attitudes, voting systems, social choice, public choice, requirements engineering and.

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Am J Sports Med. 2018 Sep;46(11):2669-2677. doi: 10.1177/0363546518785973. Epub 2018 Aug 6. Comparative Matched-Pair Analysis of Open-Wedge High Tibial Osteotomy With Versus Without an Injection of Adipose-Derived Mesenchymal Stem Cells for Varus Knee Osteoarthritis: Clinical and Second-Look Arthroscopic Results. Kim YS(1), Koh YG(1). Author information: (1)Center for Stem Cell & Arthritis.
Then, I try to conduct difference in difference analysis on these matched pairs. There are 99,374 patent-year observations generated by these 11,091 pairs of matched patents. I posted my code.
Matched Molecular Pair Analysis in Drug Discovery Drug Discov Today. 2013 Aug;18(15-16):724-31. doi: 10.1016/j.drudis.2013.03.003. Epub 2013 Apr 2. Authors Alexander G Dossetter 1 , Edward J Griffen, Andrew G Leach. Affiliation 1 MedChemica Limited, Ebenezer House.
Bei einem Matched Pair Design werden zunächst Zwillingsoder Mehrlingspaare gesucht, die sich in Hinblick auf bestimmte Attribute ähneln, denen eine Einfluss auf die Wahrscheinlichkeit und Häufigkeit der Begehung von Straftaten zugeschrieben wird. Diese Paare werden dann gezielt getrennt und unterschiedlichen Interventionsgruppen zugewiesen, damit die für relevant gehaltenen Attribute.

Manatunga A, Oakes D: Parametric analysis for matched pair survival data. Lifetime Data Anal. 1999, 5: 371-387. 10.1023/A:1009692210273. Mehrotra D, Su S, Li X: An efficient alternative to the stratified cox model analysis. Stat Med. 2012, 31: 1849-1856. 10.1002/sim.5327. Article PubMed Google Scholar 27. Katsahian S, Latouche A, Mary J, Chevret S, Porcher R: Practical methodology of meta. Protektive Stentimplantation nach erfolgreicher Rekanalisation von chronischen Koronarverschlüssen: Eine Matched-Pair-Analyse in 100 Patienten Zeitschrift: Clinical Research in Cardiology > Ausgabe 12/1998 Autoren: S. Fratz, T. Meinertz, C.A. Nienabe

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Propensity Score Matching Each RHC+ was matched with a RHC- with same disease category & closest PS (+/-0.03). Difference in PS for each pair calculated, & each pair with a positive difference matched with pair having negative difference closest in magnitude. −Assures equal numbers of pairs with positive & negative propensity differences
Matched-Pair Analysis Matched-Pair Analysis is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity
formatics and bioinformatics. Matched peptides correspond to single-point mutants, which are easily identified via pairwise sequence alignments, simplifying the data analysis. Differences in molecular properties may be identified via the matched.

Matched Molecular Pair Analysis (MMPA) can help multiple parameter optimisation. Med. Chem., 18 (2010), pp. 4405-4414. Google Scholar. 16. A.G. Dossetter, et al.A matched molecular pair analysis of in vitro human microsomal metabolic stability measurements for heterocyclic replacements of di-substituted benzene containing compounds - identification of those isosteres more likely to have.
Matched molecular pair analysis (MMPA) has become a major tool for analyzing large chemistry data sets for promising chemical transformations. However, the dependence of MMPA predictions on data constraints such as the number of pairs involved, experimental uncertainty, source of the experiments, and variability of the true physical effect has not yet been described. In this contribution the.
In the seventh randomised matched-pair study (22 pairs, [...] melanoma without metastases) there was a trend showing that survival time in patients treated with mistletoe therapy was longer (hazard rate 0.47, 95% confidence interval: 0.19-1.14) and the time to event was significantly longer (hazard rate 0.49; 95% confidence interval 0.32-0.75) compared to control group
Zur Homogenisierung werden andere Erhebungsverfahren, z.B. die matched-pairs-Technik eingesetzt, die eine Strukturgleichheit bezüglich Alter und Geschlecht sowie weiterer möglicher Störgrößen zwischen den Fällen und Kontrollen erzielen soll. Fall-Kontroll-Studien dienen der Analyse der Ätiologie unerwünschter Wirkungen. Inzidenzaussagen.
The first large scale analysis of in vitro absorption, distribution, metabolism, excretion, and toxicity (ADMET) data shared across multiple major pharma has been performed. Using advanced matched molecular pair analysis (MMPA), we combined data from three pharmaceutical companies and generated ADMET rules, avoiding the need to disclose the full chemical structures
Post-transplant lymphoproliferative disorder (PTLD) adversely affects patients' long-term outcome. The paired t test and McNemar's test were applied in a retrospective 1:1 matched-pair analysis including 36 patients with PTLD and 36 patients without PTLD after kidney or liver transplantation. Matching criteria were age, gender, indication, type of transplantation, and duration of follow-up

Matched-Pair-Studien « Klinische Studien « Klinische

In the seventh randomised matched-pair study (22 pairs, melanoma [...] without metastases) there was a trend showing that survival time in patients treated with mistletoe therapy was longer (hazard rate 0.47, 95% confidence interval: 0.19-1.14) and the time to event was significantly longer (hazard rate 0.49; 95% confidence interval 0.32-0.75) compared to control group Matched pair-analysis. Each foreign patient was matched with one German control patient in a fashion blinded to patients' outcomes. The criteria for the matching process were defined as follows: Diagnosis (based on ICD-10 and ICD-O-3), disease status (primary case vs. recurrence), tumor stage (UICC status for solid tumors, Ann-Arbor status for lymphomas, Durie and Salmon status for multiple. A matched molecular pair (MMP) analysis was used to examine the change in melting point (MP) between pairs of similar molecules in a set of ∼275k compounds. We found many cases in which the change in MP (ΔMP) of compounds correlates with changes in functional groups. In line with the results of a previous study, correlations between ΔMP and simple molecular descriptors, such as the number. The study was performed as a matched-pair-analysis, where patients of the two treatment groups were required to individually match for nine factors. Since another randomized trial would be difficult to perform, a matched-pair study is the best alternative design to reduce the risk of selection biases. Patients and methods. A total of 252 patients with a Karnofsky performance score (KPS) of.

matched-pair analysis, with 16 of them being primary kidney-transplanted patients and 20 primary liver trans-planted patients. Five patients with PTLD were excluded due to the lack of available data on important risk fac-tors or inability to find an appropriate matching case without PTLD during follow-up. Within the group of 16 kidney-transplanted patients, nine were female and seven were male. Med. Chem. 2011, 54 (22), pp.7739-7750. 3 Leach, A.G. et. al. Matched Molecular Pairs as a Guide in the Optimization of Pharmaceutical Properties; a Study of Aqueous Solubility, Plasma Protein Binding and Oral Exposure However, the study was based on matched-pair analyses of only 58 male breast carcinomas and three matching criteria (age, year of diagnosis, stage). Tumor differentiation, hormone receptor status and HER2 positivity were not considered. This might reflect an incomplete matching procedure and could better explain the divergent findings to our results. Conclusion. Our retrospective study showed. Pharmacophore extraction from Matched Molecular Pair Analysis MedChemica publishes J Med Chem paper on building a massive rule database for medicinal chemistry. January 18th, 2018 | 0 Comments. News. SpotDesign: MedChemica's Multiparameter ADMET optimisation tool is now available; MedChemica quick read: AI, Big Data and the Medicinal Chemist now online. MedChemica publishes Drug.

Refubium - Matched-Pair-Analyse: Intensitätsmodulierte

The case-control matching procedure is used to randomly match cases and controls based on specific criteria. MedCalc can match on up to 4 different variables. In the example we will use the following data: The treated cases are coded 1, the controls are coded 0. For each treated case MedCalc will try to find a control case with matching age and. analysis—part 14 of a series on evaluation of scientific publications. Dtsch Arztebl Int 2010; 107(44): 776-82. DOI: 10.3238/arztebl.2010.0776 Bei statistischen Auswertungen von medizini-schen Daten besteht das Ziel oft darin, Zusam-menhänge zwischen zwei oder mehreren Variablen zu beschreiben. Es ist beispielsweise nicht nur interes-sant, ob Patienten einen erhöhten Blutdruck haben. DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage.. Mismatch repair is strand-specific. During DNA synthesis the newly synthesised (daughter) strand will commonly include errors Das IQWiG untersucht als unabhängiges wissenschaftliches Institut im Auftrag des Gemeinsamen Bundesausschusses oder des Bundesgesundheitsministeriums den Nutzen medizinischer Leistungen für den Patienten. Neben der Vorstellung der Arbeitsbereiche und der bearbeiteten Projekte finden sich eine Übersicht über Publikationen sowie ein Bereich mit Pressematerialien

Matched Pair - Studie zur Sicherheit der Stammzellspende

Matching is based on propensity scores estimated with logistic regression. (see previous post on propensity score analysis for further details). The output below indicates that the propensity score matching creates balance among covariates/controls as if we were explicitly trying to match on the controls themselves. R Code
Objective: To compare long term outcome of highly active patients with anterior cruciate ligament ruptures treated operatively versus non-operatively. Design: We reviewed high level athletes with an anterior cruciate ligament rupture on either MRI or arthroscopic evaluation more than 10 years previously, who were treated conservatively. They were pair-matched with patients who had had an.
How to calculate the required sample size for the analysis of the mean difference between paired samples. The sample size takes into account the required significance level and power of the test
Matched-Pair Analysis Northern and Southern Hemispheres 2013-2014 and Hong Kong, China 2004-2009 Abstract Background: The matched-pair analysis does not compare between viruses the magnitude of positivity rates or the number of positive specimens from different regions. Each virus among n is match-paired with itself in the two responses of its own partial table. The Cochran-Mantel-Haenszel.
The final matched-pair samples contain both closely matched individual pairs and balanced case and contro l groups. In this paper, SAS/STAT LOGISTIC procedure code is given to create the propensity score. The matching macro is explained and used to create several propensity score matched-pair samples. The examples were run under SAS 8.2. Knowledge of l ogistic regression analysis and SAS macro.

A matched-pair analysis has been performed at the Centre for Reproductive Medicine of the UZ Brussel, Dutch speaking Free University of Brussel. A total of 410 pregnancies resulted in birth beyond 20 weeks of gestation occurring over a period of 10 years, including 205 oocyte donation pregnancies and 205 ICSI pregnancies with autologous oocytes. Therefore, only patients who, in retrospect, would not have required intubation were included in the matched-pairs analysis to evaluate the risks related to intubation. Methods The data of 42,248 patients taken from the trauma registry of the German Association for Trauma Surgery (Deutsche Gesellschaft für Unfallchirurgie (DGU)) were analyzed

Matched Pair-Analyse winkelstabiler Plattenosteosynthesen

Matched pair criteria (age, presence of an accompanying meniscus tear or cartilage injury, additional meniscus or cartilage surgery), the surgeon performing the operation (senior author J.H.), graft selection (patients were free to choose the desired graft), the surgical techniques and the rehabilitation protocol were identical to the studies published in the apron [23, 28] Patients with. To set up the analysis we first need to specify which pairs of variables we want to add to the analysis. We only have one sensible pair available here - but if we had more, we could run multiple t-tests simultaneously. For this example we want to compare the scores in the black_errors and white_errors conditions. To start the analysis, SELECT the both of these conditions (while holding down.

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According to our established matched-pair analysis, a total of 20 non-union patients were included into the current study (8 females and 12 males). Included patients were an average of 50.8 ± 11.5 years old. Statistically, patients of both groups had resembling characteristics regarding gender, age, BMI, smoking habits, diabetes, localization of the non-union, nail or plate fixation, and.
Matched pairs analysis is to be preferred in our setting, because the comparison with an historical control group is likely to be biased by heterogeneity between groups. The matched pairs are similar in respect to the most important factors which may bias treatment differences. Analyzing patients' preoperative risk factors and characteristics no significant differences in-between study.
e the genetic makeup of cancer cells
In the matched-pair analysis, the rate of sepsis and the length of the ICU stay were significantly lower in women and the mortality rate showed no significant difference (28.1% for male patients versus 33.01% for female patients). Women died after an average of 5.22 days, and men died after an average of 9.02 days. Gender-based differences in patient outcome after severe trauma were observed.
a matched pair analysis Piya Pinsornsak1*, Adisai Chaiwuttisak1 and Krit Boontanapibul2 Abstract Background: Theoretically, potential errors in femoral component (FC) sizing can affect postoperative functional outcomes after total knee arthroplasty (TKA), including range of motion (ROM), anterior knee pain, and flexion stability. Incidences of asymmetrical femoral components (AFC) in bilateral.
When some or all of the effect of a predictor on the response results from an intermediary variable, then that variable is said to mediate the effect of the predictor. Mediation analysis provides estimates of the direct, indirect, and total effects of the predictor
Ten year follow-up study comparing conservative versus operative treatment of anterior cruciate ligament ruptures: a matched-pair analysis of high level athletes. Br J Sports Med 2009;43: 347-351.

Purpose:Athletes often receive conservative treatment for injured anterior cruciate ligaments (ACLs) so that they can continue to play to the end of their season. The purpose of this study was to e.. A matched-pair analysis comparing 5x4 Gy and 10x3 Gy for metastatic spinal cord compression (MSCC) in patients with favorable survival prognoses. Dirk Rades 1, Stefan Huttenlocher 1, Theo Veninga 2, Amira Bajrovic 3, Michael Bremer 4, Volker Rudat 5 & Steven E Schild 6 Radiation Oncology volume 10, Article number: 90 (2015) Cite this article. 1716 Accesses. 2 Citations. 4 Altmetric. Metrics. Matched-Molecular Pair (MMP) analysis has recently emerged as a data analysis technique in medicinal chemistry. It quickly gained scientific momentum because it tackles key questions in lead optimization. In contrast to classical global QSAR models that attempt to predict the absolute numbers of ADME (absorption, distribution, metabolism, excretion) and toxicological properties, MMP analyses. Abstract - Multiple parameter optimisation in drug discovery is difficult, but Matched Molecular Pair Analysis (MMPA) can help. Computer algorithms can process data in an unbiased way to yield design rules and suggest better molecules, cutting the number of design cycles. The approach often makes more suggestions than can be processed manually and methods to deal with this are proposed.

Methods: A matched-pair analysis has been performed at the Centre for Reproductive Medicine of the UZ Brussel, Dutch speaking Free University of Brussel. A total of 410 pregnancies resulted in birth beyond 20 weeks of gestation occurring over a period of 10 years, including 205 oocyte donation pregnancies and 205 ICSI pregnancies with autologous oocytes (AO). Patients in the OD group were. Perineal trauma during childbirth affects millions of women worldwide every year. The aim of the Perineal Assessment and Repair Longitudinal Study (PEARLS) was to improve maternal clinical outcomes following childbirth through an enhanced cascaded multiprofessional training program to support implementation of evidence-based perineal management. This was a pragmatic matched-pair cluster.

Aufgabe 10: Fall-Kontroll-Studien − Matched-Pairs-Techni

A matched design comes about when randomisation is between matched pairs, such as in Exercise 6.2, in which randomisation was between different parts of a patient's body. A crossover study is one in which two or more treatments are applied sequentially to the same subject. The advantages are that each subject then acts as their own control and so fewer subjects may be required. The main.
Matched pairs analysis provide the opportunity to rule out confounders by providing structural equality of cases and controls concerning known risk factors. This structural equality proved to be given in this analysis since there are neither numeral nor statistical differences in the preoperative risk factors for developing postoperative AKI
Chemokine analysis as a novel diagnostic modality in the early prediction of the outcome of non-union therapy: a matched pair analysis Patrick Haubruck1,2*, Anja Solte1, Raban Heller1, Volker Daniel3, Michael Tanner1, Arash Moghaddam1,4, Gerhard Schmidmaier1 and Christian Fischer1 Abstract Background: Despite the regenerative capability of skeletal tissue fracture, non-union is common.
Matched-Pair Analysis - A type of analysis in which subjects in a study group and a comparison group are made comparable with respect to extraneous factors by individually pairing study subjects with the comparison group subjects (e.g., age-matched controls). Meta-Analysis - Works consisting of studies using a quantitative method of combining.
Matched molecular pairs (MMPs), i.e., pairs of compounds that are related to each other by a specific molecular transformation, have become an integral tool of drug discovery [1, 2].Generally spoken, matched molecular pair analysis (MMPA) aims at the extraction of all MMPs from a set of compounds and their association with calculated or measured property changes

Network meta-analysis, in the context of a systematic review, is a meta-analysis in which multiple treatments (that is, three or more) are being compared using both direct comparisons of interventions within randomized controlled trials and indirect comparisons across trials based on a common comparator. To ensure validity of findings from network meta-analyses, the systematic review must be. Single-nucleotide polymorphisms may fall within coding sequences of genes, non-coding regions of genes, or in the intergenic regions (regions between genes). SNPs within a coding sequence do not necessarily change the amino acid sequence of the protein that is produced, due to degeneracy of the genetic code.. SNPs in the coding region are of two types: synonymous and nonsynonymous SNPs

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Another method of analysis for matched pairs data is a distribution-free test known as the sign test. This test does not require any normality assumptions about the data, and simply involves counting the number of positive differences between the matched pairs and relating these to a binomial distribution. The concept behind the sign test reasons that if there is no true difference, then the.
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For the osteoporosis cohort, there were 16,235 matched pairs. During 13,496 person-years of follow-up, patients receiving zoledronic acid experienced 251 atrial fibrillation events, while for.
We store pairs of values in a single List—2 Lists could be used, but that might complicate matters. Part 1: We initialize a List of pairs. Each pair has 2 types separated by a comma (string, int). Part 2: KeyValuePairs are immutable, so we cannot change them after they are created, but we can print them. Console. C# program that uses KeyValuePair using System; using System.Collections.

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Szaki et al. Emerg Themes Epidemiol DOI10.1186/12982-017-0060-8 ANALYTICPERSPECTIVE Od ratio estimators by˜proportional hazards models in˜matched -pair cohort studies Tomohiro Shinozaki1*,Mohammad Ali Mansournia2and Yutaka Matsuyama1 Abstrac According to the Louisville Statement, laparoscopic major hepatectomy is a heterogeneous category that includes traditional trisectionectomies/hemi. matching pairs that had comparable gender, age, severity of traumatic brain injury, initial GCS, presence/absence of shock. To create two study groups, one partner of every pair had additional thoracic injuries of varying de-grees (i.e. AIS Thorax =2, 3, 4 or 5) (Fig. 1). Matching pairs were included in the statistical analysi Etanercept has been approved in polyarticular juvenile idiopathic arthritis (JIA) patients refractory or intolerant to methotrexate. The objectives of the study were to evaluate safety and efficacy of Etanercept and Methotrexate combination therapy versus Etanercept mono therapy in JIA using a matched pair analysis Unsere Bestenliste 10/2020 - Ausführlicher Test Ausgezeichnete Cord Schlaghose Bester Preis Preis-Leistungs-Sieger - JETZT direkt weiterlesen

The sensitivity analysis (702 pairs of the matching) showed a significantly higher survival rate in the closed ICU (71.8% vs 65.2%, p = 0.011). The length of ICU stay of patients in closed ICUs was significantly shorter (20% less). This Japanese nationwide analysis of patients with sepsis shows a significant association between treatment in a.